Azobisisobutyronitrile → HCID 23033213、化合物
反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:13]([O-:15])=[O:14])=[C:6]([CH:12]=1)[C:7]([N:9]([CH3:11])[CH3:10])=[O:8].[Br:16]N1C(=O)CCC1=O.N(C(C)(C)C#N)=NC(C)(C)C#N>C(Cl)(Cl)(Cl)Cl>[Br:16][CH2:1][C:2]1[CH:3]=[CH:4][C:5]([N+:13]([O-:15])=[O:14])=[C:6]([CH:12]=1)[C:7]([N:9]([CH3:10])[CH3:11])=[O:8]参加物
5
反応条件
- 温度
- 90 °C
実験手順
The 5, N,N-Trimethyl-2-nitrobenzamide (4.16 g) obtained in Example 9-5b), N-bromosuccinimide (3.56 g) and 2,2′-azobisisobutyronitrile (328 mg) were suspended in carbon tetrachloride (80 mL). The suspension was stirred at 90° C. for 2 hours, filtered through a Celite pad and purified by column chromatography on silica gel with hexane:ethyl acetate=5:4 to give the title compound (602 mg).
後処理
- filtrationfiltered through a Celite pad
- custompurified by column chromatography on silica gel with hexane
出典と根拠
- ORDレコード
- ord-1934b4dd044a4ee392ca3247fbb746b3
- 出典データセット
- uspto-grants-2009_05
- 特許番号
- US07538140B2
反応ノート
読み込み中…