Methanol → HCID 57682769、化合物

HRID 494999ノート

反応式

HRID 494999 の反応式
CO.O1CCCC1.C([O:15][C:16]1[C:21]([C:22]([NH:24][CH3:25])=[O:23])=[CH:20][CH:19]=[C:18]([O:26][CH3:27])[C:17]=1[CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][CH:33]([N:36]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([C:45]([NH2:47])=[O:46])[CH:43]=3)[CH:38]=[CH:37]2)[CH2:32][CH2:31]1)C1C=CC=CC=1>[Pd]>[OH:15][C:16]1[C:21]([C:22]([NH:24][CH3:25])=[O:23])=[CH:20][CH:19]=[C:18]([O:26][CH3:27])[C:17]=1[CH2:28][CH2:29][N:30]1[CH2:35][CH2:34][CH:33]([N:36]2[C:44]3[C:39](=[CH:40][CH:41]=[C:42]([C:45]([NH2:47])=[O:46])[CH:43]=3)[CH:38]=[CH:37]2)[CH2:32][CH2:31]1

参加物

5

反応物 3

HCID 887MethanolHCID 8028TetrahydrofuranHCID 57682824HCID 57682824、化合物

生成物 1

HCID 57682769HCID 57682769、化合物収率 100.7%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

15 ml of methanol and 10 ml of tetrahydrofuran were added to and dissolved in 486 mg of 1-(1-(2-(2-(benzyloxy)-6-methoxy-3-((methylamino)carbonyl)phenyl)ethyl)piperidin-4-yl)-1H-indole-6-carboxamide. Thereafter, 74 mg of 10% Pd—C (containing water) was added thereto, and the obtained mixture was then stirred at room temperature under hydrogen atmosphere overnight. Thereafter, Pd—C was removed by filtration, and the solvent was removed under a reduced pressure, so as to obtain 408 mg of the subject compound.

後処理

  1. customThereafter, Pd—C was removed by filtration
  2. customthe solvent was removed under a reduced pressure

出典と根拠

ORDレコード
ord-91cafb84c28b4cf8b1577b4afd28299c
出典データセット
uspto-grants-2009_05
特許番号
US07538123B2

反応ノート

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