Tetrahydrofuran → 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide L-(+)-tartrate

HRID 495010ノート

反応式

HRID 495010 の反応式
[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:35])([CH3:34])[O:10]2)=[CH:5][CH:4]=1.O1CCCC1.[C:42]([OH:51])(=[O:50])[C@@H:43]([C@H:45]([C:47]([OH:49])=[O:48])[OH:46])[OH:44]>C(OCC)C>[C:47]([C@@H:45]([C@H:43]([C:42]([OH:51])=[O:50])[OH:44])[OH:46])([OH:49])=[O:48].[CH3:1][O:2][C:3]1[C:12]([CH2:13][CH2:14][N:15]2[CH2:20][CH2:19][CH:18]([N:21]3[C:29]4[C:24](=[CH:25][CH:26]=[C:27]([C:30]([NH:32][CH3:33])=[O:31])[CH:28]=4)[CH:23]=[CH:22]3)[CH2:17][CH2:16]2)=[C:11]2[C:6]([C:7](=[O:36])[CH2:8][C:9]([CH3:34])([CH3:35])[O:10]2)=[CH:5][CH:4]=1

参加物

5

反応物 3

HCID 8028Tetrahydrofuran2 回HCID 444305L-Tartaric acidHCID 11677552E-2110 free base

生成物 1

HCID 866016071-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide L-(+)-tartrate収率 84.2%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

1-{1-[2-(7-Methoxy-2,2-dimethyl-4-oxochroman-8-yl)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide (100 mg) was dissolved in a mixed solvent consisting of tetrahydrofuran (1 ml) and diethyl ether (25 ml). Thereafter, a mixed solvent consisting of tetrahydrofuran (1 ml) and diethyl ether (25 ml) containing L-(+)-tartaric acid (31 mg) was added to the reaction solution at room temperature. The deposited solid was collected by filtration, and the obtained product was then washed with diethyl ether, so as to obtain the subject compound (110 mg).

後処理

  1. additionwas added to the reaction solution at room temperature
  2. filtrationThe deposited solid was collected by filtration
  3. washthe obtained product was then washed with diethyl ether

出典と根拠

ORDレコード
ord-6da6a0d92e6849b8bdd44d6806ab5369
出典データセット
uspto-grants-2009_05
特許番号
US07538123B2

反応ノート

読み込み中…