Benzaldehyde → HCID 69497995、化合物

HRID 495320

反応式

HRID 495320 の反応式
[C:1]1(=[O:6])[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-:7].[Na+].[CH:9](=O)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.[O:17]1[CH2:22][CH2:21][CH2:20][CH2:19][CH:18]1[O:23][C:24]1[CH:31]=[CH:30][C:27]([CH:28]=O)=[CH:26][CH:25]=1>C(O)C.O>[O:7]1[CH2:5][CH2:4][CH2:3][CH2:2][CH:1]1[O:6][C:13]1[CH:14]=[CH:15][C:10]([CH:9]=[C:2]2[CH2:3][CH2:4][C:5](=[CH:28][C:27]3[CH:30]=[CH:31][C:24]([O:23][CH:18]4[CH2:19][CH2:20][CH2:21][CH2:22][O:17]4)=[CH:25][CH:26]=3)[C:1]2=[O:6])=[CH:11][CH:12]=1

参加物

7

反応物 4

HCID 240BenzaldehydeHCID 8452CyclopentanoneHCID 14798Sodium HydroxideHCID 112527364-(2-Tetrahydro-2H-pyranoxy)benzaldehyde

生成物 1

HCID 69497995HCID 69497995、化合物収率 74%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒2 回HCID 962Water溶媒

実験手順

Cyclopentanone (8.8 ml, 0.099 mol) was dissolved in ethanol (12 ml) and added to NaOH dissolved in water (25 ml) and ethanol (7 ml), and was left to stir for 25 min. This was then added to the THP protected benzaldehyde from 1CW01 (46.12 g, 0.22 mol), and the mixture was left to stir at room temperature for approximately 16 hours. A solid precipitate was isolated by vacuum filtration, washed with water (2×50 ml) and then ethanol (4×40 ml). This solid was recrystallised from ethanol to give a yellow solid (33.74 g, 74%).

後処理

  1. additionThis was then added to the THP
  2. waitthe mixture was left
  3. stirringto stir at room temperature for approximately 16 hours
  4. customA solid precipitate was isolated by vacuum filtration
  5. washwashed with water (2×50 ml)
  6. customThis solid was recrystallised from ethanol

出典と根拠

ORDレコード
ord-0dc7a94483894b17b716ed6beacbeb41
出典データセット
uspto-grants-2005_09
特許番号
US06939479B2

関連ノート

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