Hydrochloric Acid → Ethyl 2-chlorophenylcarbamate

HRID 495611

反応式

HRID 495611 の反応式
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].Cl[C:10]([O:12][CH2:13][CH3:14])=[O:11].Cl>N1C=CC=CC=1>[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[CH:5][C:3]=1[NH:4][C:10](=[O:11])[O:12][CH2:13][CH3:14]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 72402-ChloroanilineHCID 10928Ethyl chloroformate

生成物 1

HCID 528085Ethyl 2-chlorophenylcarbamate収率 98%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

2-Chloroaniline (1.4463 g) was dissolved in pyridine (10 ml), and to the solution was added dropwise ethyl chloroformate (1.30 ml) under ice-cooling. After the mixture was stirred for 1 hour, 1N hydrochloric acid was added and the mixture was extracted with ethyl acetate. The organic layer was washed with 1N hydrochloric acid, and then saturated brine, dried over anhydrous magnesium sulfate, and concentrated in vacuo to give the title compound (2.2203 g, 98%).

後処理

  1. temperaturecooling
  2. extractionthe mixture was extracted with ethyl acetate
  3. washThe organic layer was washed with 1N hydrochloric acid
  4. dry with materialsaturated brine, dried over anhydrous magnesium sulfate
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-20e2a6910ef245dda1b9bea78eba1ec0
出典データセット
uspto-grants-2005_09
特許番号
US06939887B2

関連ノート

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