Acetamide → N-Acetyl-1,6-diaminohexane

HRID 49563

反応式

HRID 49563 の反応式
[NH2:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH2:8].[C:9](N)(=[O:11])[CH3:10]>>[C:9]([NH:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][NH2:8])(=[O:11])[CH3:10]

参加物

3

反応物 2

HCID 178AcetamideHCID 16402Hexamethylenediamine

生成物 1

HCID 162081N-Acetyl-1,6-diaminohexane

実験手順

Hexamethylenediamine (90.64 g; 0.6 mol) and acetamide (11.81 g; 0.2 Mol) were stirred and refluxed for 10 hours under nitrogen. The solution was cooled overnight and then distilled under vacuum <100° C. as fast as possible. The N-acetylhexylenediamine was then separated from the resultant mixture by flash chromatography [SiO2/EtOH:25%aq.NH3 (4:1)]. The title product was obtained as a white crystalline product (18.43 g; 58% theory).

後処理

  1. temperaturerefluxed for 10 hours under nitrogen
  2. temperatureThe solution was cooled overnight
  3. distillationdistilled under vacuum <100° C. as fast as possible
  4. customThe N-acetylhexylenediamine was then separated from the resultant mixture by flash chromatography [SiO2/EtOH:25%aq.NH3 (4:1)]

出典と根拠

ORDレコード
ord-35c5df770b194cc5a9ffc293550b73f2
出典データセット
uspto-grants-2004_03
特許番号
US06706855B1

関連ノート

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