Iodine chloride → 2-Amino-5-iodobenzenesulfonamide

HRID 496122ノート

反応式

HRID 496122 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[S:8]([NH2:11])(=[O:10])=[O:9].[I:12]Cl>C(Cl)(Cl)Cl>[I:12][C:5]1[CH:6]=[CH:7][C:2]([NH2:1])=[C:3]([S:8]([NH2:11])(=[O:9])=[O:10])[CH:4]=1

参加物

4

反応物 2

HCID 24640Iodine chlorideHCID 728942-Aminobenzenesulfonamide

生成物 1

HCID 223240882-Amino-5-iodobenzenesulfonamide収率 92%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a cold (0° C.) stirred solution of 2-aminobenzenesulfonamide (17.2 g; 100 mmol) in CHCl3 (200 ml) was added a solution of iodine monochloride (17.1 g; 105 mmol) in CHCl3 (50 ml) over 1 h. The reaction mixture was slowly warmed up to rt. and left with stirring over night. The reaction mixture was filtered and the isolated solid was washed on the filter with CHCl3 (3×20 ml), NaHCO3 (sat. aq., 1×20 ml), H2O (4×50 ml). The isolated solid was air dried to give 27.3 g (92%) of product.

後処理

  1. waitand left
  2. filtrationThe reaction mixture was filtered
  3. washthe isolated solid was washed on the
  4. filtrationfilter with CHCl3 (3×20 ml), NaHCO3 (sat. aq., 1×20 ml), H2O (4×50 ml)
  5. customdried

出典と根拠

ORDレコード
ord-dcd13d7f0bdc4a148a5865aa46d4f205
出典データセット
uspto-grants-2005_09
特許番号
US06943159B1

反応ノート

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