Hydrogen Bromide → 4-(Naphth-1-yl)piperidine hydrobromide

HRID 4964

反応式

HRID 4964 の反応式
[C:1]1([CH:11]2[CH2:16][CH2:15][N:14](NC(=O)OCC)[CH2:13][CH2:12]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[BrH:23]>>[BrH:23].[C:1]1([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 54406105Ethyl [4-(naphth-1-yl)piperid-1-yl]carbamate

生成物 1

HCID 190962204-(Naphth-1-yl)piperidine hydrobromide収率 86.64%

実験手順

10.5 g of the compound obtained in Stage A in 300 ml of a 48% hydrobromic acid solution, are refluxed for 20 hours. After evaporation and washing twice with ethanol, the residue is taken up in acetone and the mixture then filtered to give 4-(naphth-1-yl)piperidine hydrobromide.

後処理

  1. customAfter evaporation
  2. washwashing twice with ethanol
  3. filtrationthe mixture then filtered

出典と根拠

ORDレコード
ord-2b73ef6cf0d74456b104b1399812863b
出典データセット
uspto-grants-1993_09
特許番号
US05242933

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