Pyrazole → 3-(1H-pyrazol-1-yl)propanoic acid
反応式
[NH:1]1[CH:5]=[CH:4][CH:3]=[N:2]1.[C:6]([OH:10])(=[O:9])[CH:7]=[CH2:8]>C(N(CC)CC)C>[N:1]1([CH2:8][CH2:7][C:6]([OH:10])=[O:9])[CH:5]=[CH:4][CH:3]=[N:2]1参加物
4
実験手順
In a 10 mL round-bottomed flask equipped with a condenser and a stirring bar was placed pyrazole (0.50 g, 7.3 mmol), acrylic acid (0.50 mL, 7.3 mmol) and triethylamine (3 mL). The reaction mixture was refluxed for 6 hours. After removing triethylamine, the viscous oil was dried on high vacuo during 12 hours to yield quantitatively the desired acid (1.0 g) suitable for the next step without further purification.
後処理
- customIn a 10 mL round-bottomed flask equipped with a condenser and a stirring bar
- temperatureThe reaction mixture was refluxed for 6 hours
- customAfter removing triethylamine
- customthe viscous oil was dried on high vacuo during 12 hours
出典と根拠
- ORDレコード
- ord-722df924973d401887292c8a632727dd
- 出典データセット
- uspto-grants-2005_09
- 特許番号
- US06946481B1
反応ノート
読み込み中…