Water → HCID 86759852、化合物

HRID 497726

反応式

HRID 497726 の反応式
Cl[C:2]1[C:3]2[S:20][C:19]([NH2:21])=[N:18][C:4]=2[N:5]=[C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:11]=2[F:17])[N:7]=1.[NH2:22][CH2:23][C@H:24](O)[CH3:25].[OH2:27]>CN1CCCC1=O.CCN(C(C)C)C(C)C>[NH2:21][C:19]1[S:20][C:3]2[C:2]([NH:22][CH:23]([OH:27])[CH2:24][CH3:25])=[N:7][C:6]([S:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[C:12]([F:16])[C:11]=3[F:17])=[N:5][C:4]=2[N:18]=1

参加物

6

反応物 3

HCID 962WaterHCID 439938(2R)-1-aminopropan-2-olHCID 112216507-Chloro-5-[[(2,3-difluorophenyl)methyl]thio]-thiazolo[4,5-d]pyrimidin-2-amine

生成物 1

HCID 86759852HCID 86759852、化合物

試薬・触媒・溶媒 2

HCID 13387N-methyl-2-pyrrolidone溶媒HCID 81531Diisopropylethylamine溶媒

実験手順

The product from example 1, step (b) (70.0 g) and (R)-1-amino-propan-2-ol (32 ml) in N-methylpyrrolidinone (600 ml) and Hunigs base (71 ml) was heated at 110° C. for 16 hours. The mixture was poured into water (5 L) and the crude product collected at by filtration. This solid was purified by recrystallisation from acetonitrile (2.5 L) to give 65 g of the subtitled compound.

後処理

  1. filtrationthe crude product collected at by filtration
  2. customThis solid was purified by recrystallisation from acetonitrile (2.5 L)

出典と根拠

ORDレコード
ord-1c6fd978249740a2a653eae94ca91aa6
出典データセット
uspto-grants-2005_09
特許番号
US06949643B2

関連ノート

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