2,6-Dichloropyridine → 2-Chloro-6-hydrazinopyridine

HRID 497993

反応式

HRID 497993 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.O.[NH2:10][NH2:11]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:10][NH2:11])[N:3]=1

参加物

3

反応物 2

HCID 169892,6-DichloropyridineHCID 24654Hydrazine hydrate (1:1)

生成物 1

HCID 3200042-Chloro-6-hydrazinopyridine収率 65.1%

反応条件

温度
100 °C

実験手順

The title compound was prepared according to the method described in U.S. Pat. No. 4,260,767 (1981). A mixture of 2,6-dichloropyridine (25.0 g, 169 mmol) and hydrazine monohydrate (60 mL, 1.24 mol) was heated and stirred at 100° C. for 4 hours. The solution was ice cooled, and the resulting crude crystals were collected by filtration. The crystals were washed with cold water and air dried. The crystals thus obtained were recrystallized from chloroform/hexane to give the title compound (15.8 g, 65% yield).

後処理

  1. customThe title compound was prepared
  2. temperaturewas heated
  3. temperaturecooled
  4. filtrationthe resulting crude crystals were collected by filtration
  5. washThe crystals were washed with cold water and air
  6. customdried
  7. customThe crystals thus obtained
  8. customwere recrystallized from chloroform/hexane

出典と根拠

ORDレコード
ord-86ee93274f1242f89fa1d58b842fc784
出典データセット
uspto-grants-2005_09
特許番号
US06949648B2

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