1-Pentanethiol → HCID 22939283、化合物

Pentyl mercaptan (0.83 g, 7.9 mmol) was dissolved in tetrahydrofuran (100 ml) and added dropwise to sodium hydride (60% oil, 0.35 g, 8.7 mmol). The reaction mixture was stirred at room temperature for 1 hr. A solution of 2-chloro-6-cyanopyridine (1.00 g, 7.2 mmol) in tetrahydrofuran (10 ml) was added to the mixture, and the mixture was stirred at room temperature for 18 hrs. The reaction mixture was concentrated under reduced pressure, diluted with water and extracted with ethyl acetate. The extract was washed with saturated brine and dried. The solvent was evaporated under reduced pressure to give the titled compound (1.48 g, ca. 100%) as an oil.

1. stirringthe mixture was stirred at room temperature for 18 hrs
2. concentrationThe reaction mixture was concentrated under reduced pressure
3. additiondiluted with water
4. extractionextracted with ethyl acetate
5. washThe extract was washed with saturated brine
6. customdried
7. customThe solvent was evaporated under reduced pressure

ORDレコード

ord-499329ddf1794e0f8a13f03ba9b2dce8

出典データセット

uspto-grants-2010_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07767665B2