Tetrahydrofuran → (1,1'-Biphenyl)-3-carboxylic acid

HRID 49940

反応式

HRID 49940 の反応式
[C:1]1([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10]([O:12]C)=[O:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+].O1CCCC1>CO>[C:1]1([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10]([OH:12])=[O:11])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

5

反応物 3

HCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 9855857Methyl 3-phenylbenzoate

生成物 1

HCID 12854(1,1'-Biphenyl)-3-carboxylic acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

0.90 g of methyl 3-phenylbenzoate was fed into 20 ml of a solvent mixture of aqueous solution of 2 M of sodium hydroxide, tetrahydrofuran and methanol (4/2/1) to conduct the reaction at 70° C. for 2 hours. The solvent was evaporated, and the residue was fed into 3 M of hydrochloric acid. The precipitate thus formed was taken by the filtration and dried to obtain the title compound in the form of white crystals.

後処理

  1. customthe reaction at 70° C. for 2 hours
  2. customThe solvent was evaporated
  3. customThe precipitate thus formed
  4. filtrationwas taken by the filtration
  5. customdried

出典と根拠

ORDレコード
ord-b6d106859ae042a0be8637cd84cd0072
出典データセット
uspto-grants-2004_03
特許番号
US06710056B2

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