Tetrahydrofuran → 2-Cyano-6-methylthiopyrazine

HRID 499554

反応式

HRID 499554 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=1.[CH3:10][S-:11].[Na+].C1COCC1.C(OCC)(=O)C>O>[C:8]([C:4]1[CH:5]=[N:6][CH:7]=[C:2]([S:11][CH3:10])[N:3]=1)#[N:9]

参加物

6

反応物 4

HCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 813036-Chloropyrazine-2-carbonitrileHCID 4378561Sodium methanethiolate

生成物 1

HCID 229392812-Cyano-6-methylthiopyrazine収率 83%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 2-chloro-6-cyanopyrazine (1.40 g, 10.0 mmol), sodium thiomethoxide (0.78 g, 11.0 mmol) and THF (100 ml) was refluxed for 2 hrs. The reaction mixture was combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over magnesium sulfate. The solvent was evaporated to give the titled compound (1.25 g, 83%) as pale yellow crystals.

後処理

  1. temperaturewas refluxed for 2 hrs
  2. washThe organic layer was washed with saturated brine
  3. dry with materialdried over magnesium sulfate
  4. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-10c916b4118a4d4fb5af290e415fd27f
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

関連ノート

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