Dimethylamine → 6-(Dimethylamino)pyrazine-2-carbonitrile

HRID 499556

反応式

HRID 499556 の反応式
Cl[C:2]1[CH:7]=[N:6][CH:5]=[C:4]([C:8]#[N:9])[N:3]=1.[CH3:10][NH:11][CH3:12].C(#N)C.C1COCC1>O.C(OCC)(=O)C>[C:8]([C:4]1[CH:5]=[N:6][CH:7]=[C:2]([N:11]([CH3:12])[CH3:10])[N:3]=1)#[N:9]

参加物

7

反応物 4

HCID 674DimethylamineHCID 6342AcetonitrileHCID 8028TetrahydrofuranHCID 813036-Chloropyrazine-2-carbonitrile

生成物 1

HCID 232734596-(Dimethylamino)pyrazine-2-carbonitrile収率 55%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8857Ethyl Acetate溶媒

実験手順

2-Chloro-6-cyanopyrazine (0.85 g, 6.09 mmol) and 1.67 N dimethylamine in acetonitrile (4.00 ml, 6.70 mmol) were added to THF (100 ml), and the mixture was stirred at room temperature for 2 hrs. The reaction mixture was combined with ethyl acetate and water. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated to give the titled compound (0.50 g, 55%) as pale yellow crystals.

後処理

  1. washThe organic layer was washed with saturated brine
  2. dry with materialdried over anhydrous magnesium sulfate
  3. customThe solvent was evaporated

出典と根拠

ORDレコード
ord-aa45f43810d74b31af6b3328805d96d4
出典データセット
uspto-grants-2010_08
特許番号
US07767665B2

関連ノート

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