Water → (9aS)-Octahydro-2H-pyrido[1,2-a]pyrazine

温度

0 °C

(S)-Octahydro-1,4-dioxo-2H-pyrido[1,2-a]pyrazine (0.5 g, 2.98 mmol) was added portionwise to a stirred solution of lithium aluminium hydride (1M in tetrahydrofuran; 11.9 ml, 11.9 mmol). The resulting mixture was heated under reflux for 0.5 h. The solution was then cooled to 0° C. and treated dropwise with water (1.35 ml), 1 M sodium hydroxide solution (0.45 ml), then water (1.35 ml). Tetrahydrofuran (10 ml) was added and the solution stirred for 0.5 h, before filtration. The filter cake was washed with tetrahydrofuran (2×5 ml) and the combined filtrate and washings concentrated to yield (S)-octahydro-2H-pyrido[1,2-a]pyrazine as a yellow oil (0.29 g, 2.07 mmol).

1. temperatureThe resulting mixture was heated
2. temperatureunder reflux for 0.5 h
3. washThe filter cake was washed with tetrahydrofuran (2×5 ml)
4. concentrationthe combined filtrate and washings concentrated

ORDレコード

ord-5ad6a31487d34da289996b4d699885d7

出典データセット

uspto-grants-2010_08

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07772227B2