Dimethylformamide → 4-Chloro-3-methylbenzoyl chloride
反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][C:3]=1[CH3:11].CN(C=O)C.C(Cl)(=O)C([Cl:20])=O>C(Cl)Cl>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:20])=[O:7])=[CH:4][C:3]=1[CH3:11]参加物
5
実験手順
To a suspension of 52.55 g (0.31 mol) of 4-chloro-3-methyl-benzoic acid in CH2Cl2 (1.2 L) with DMF (1 mL) at 0° C. under N2 with an outlet sparging through 2.5 N sodium hydroxide was added 29.56 mL (0.339 mol) of oxalyl chloride. The mixture was allowed to warm to room temperature over a 3 h period. The reaction mixture was concentrated and taken forward crude.
後処理
- customsparging through 2.5 N sodium hydroxide
- concentrationThe reaction mixture was concentrated
出典と根拠
- ORDレコード
- ord-98621b18a7b345418321c9ad9af11e41
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07772236B2
反応ノート
読み込み中…