Sodium Hydroxide → 1-Butanol, 2-(4-pyrimidinylamino)-

HRID 501006ノート

反応式

HRID 501006 の反応式
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10][OH:11])[CH:3]=1.[OH-].[Na+]>C(O)C.[Pd]>[N:7]1[CH:2]=[CH:3][C:4]([NH:8][CH:9]([CH2:12][CH3:13])[CH2:10][OH:11])=[N:5][CH:6]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 22024413HCID 22024413、化合物

生成物 1

HCID 220243971-Butanol, 2-(4-pyrimidinylamino)-

試薬・触媒・溶媒 2

HCID 23938Palladium触媒2 回HCID 702Ethanol溶媒

実験手順

2-[(6-Chloro-4-pyrimidinyl)amino]-1-butanol was dissolved in ethanol (110 mL), which was sequentially added with a 5N aqueous sodium hydroxide solution (5.5 mL) and Pd—C (hydrous product; 0.55 g), and hydrogenation was performed under hydrogen atmosphere at a normal temperature and a normal pressure. After completion of the reaction, Pd—C was filtered off, and the solvent was evaporated. The resulting residue was extracted with dichloromethane-methanol, and the solvent was removed to give the title compound (4.3 g) as white crystals.

後処理

  1. filtrationwas filtered off
  2. customthe solvent was evaporated
  3. extractionThe resulting residue was extracted with dichloromethane-methanol
  4. customthe solvent was removed

出典と根拠

ORDレコード
ord-87ef1290369a4470ab9878b601aa1d0b
出典データセット
uspto-grants-2010_08
特許番号
US07772249B2

反応ノート

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