反応式
[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH3:10].[Br:12]N1C(=O)CCC1=O.CC(N=NC(C#N)(C)C)(C#N)C>ClC(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:11])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[CH2:10][Br:12]参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a solution of 2-methylbenzoic acid methyl ester (33.0 g) in tetrachlorocarbon (440 ml) were added N-bromosuccinimide (43.0 g) and AIBN (2,2′-azobisisobutyronitrile, 361 mg) and the mixture was refluxed for 30 minutes. The reaction mixture was cooled down to 0° C. and cinnamoic acid that appeared were filtered off and the filtrate was concentrated. The residue was purified by distillation under reduced pressure to give the title compound having the following physical data (28.0 g, colorless oil).
後処理
- temperaturethe mixture was refluxed for 30 minutes
- filtrationcinnamoic acid that appeared were filtered off
- concentrationthe filtrate was concentrated
- distillationThe residue was purified by distillation under reduced pressure
出典と根拠
- ORDレコード
- ord-a96861900862401e895e29ef678b6cde
- 出典データセット
- uspto-grants-2004_03
- 特許番号
- US06710205B2
関連ノート
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