Hydrochloric Acid → HCID 178422984、化合物
反応式
O[NH:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][C:7]([CH3:10])=[CH:6][C:5]=1[OH:11].C(N(CC)CC)C.S(Cl)(Cl)=O.Cl>O1CCCC1.O>[CH3:10][C:7]1[CH:8]=[CH:9][C:4]2[C:3]([OH:12])=[N:2][O:11][C:5]=2[CH:6]=1参加物
7
実験手順
44.0 g of N,2-dihydroxy-4-methylbenzamide was suspended in 880 mL of tetrahydrofuran, to which 147 mL of triethylamine was added dropwise at room temperature and then 28.7 mL of thionyl chloride was added dropwise at 5 to 10° C. successively, and this mixture was stirred for one hour at room temperature. The reaction mixture was added to water, and adjusted to pH 1 with 12M hydrochloric acid, and then resultant precipitate was filtered out thereof. The resultant solid was washed with water to yield 35.2 g of 6-methyl-1,2-benzisoxazol-3-ol as light yellow solid.
後処理
- additionwas added dropwise at room temperature
- filtrationresultant precipitate was filtered out thereof
- washThe resultant solid was washed with water
出典と根拠
- ORDレコード
- ord-0dbf453ba57d4c57bee8b19a1d6b81b0
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07772285B2
反応ノート
読み込み中…