Water → 3-(Benzodioxol-5-yl)propionic acid

HRID 5025

反応式

HRID 5025 の反応式
[CH2:1]1[O:14][C:13]2[CH:12]=[CH:11][C:5]([CH:6]=[CH:7][C:8]([OH:10])=[O:9])=[CH:4][C:3]=2[O:2]1.O.[H][H]>[OH-].[Na+].[Pd]>[CH2:1]1[O:14][C:13]2[CH:12]=[CH:11][C:5]([CH2:6][CH2:7][C:8]([OH:10])=[O:9])=[CH:4][C:3]=2[O:2]1

参加物

6

反応物 3

HCID 962WaterHCID 169173-(1,3-Benzodioxol-5-yl)prop-2-enoic acidHCID 178418361HCID 178418361、化合物

生成物 1

HCID 648103-(Benzodioxol-5-yl)propionic acid収率 97%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 14798Sodium Hydroxide溶媒

実験手順

To a solution of 10.0 g of 3,4-methylenedioxycinnamic acid dissolved in 130 ml of 10% NaOH and 80 ml of distilled water was added 1.0 g of 5% Pd-C. This mixture was reacted at 40 psi until the consumption of hydrogen gas was ceased and then filtered through a Celite layer. The filtrate was acidified with concentrated hydrochloric acid, allowed to be cooled and filtered to give solids. The obtained solids were washed twice with 100 ml of cold water and dried to provide 9.8 g(yield 97%) of 3-(3,4-methylenedioxyphenyl) propanoic acid, having the characteristics of: NMR(CDCl3, 200 MHz) δ2.62(t, J=7 Hz, 2H, CH2), 2.88(t, J=7 Hz, 2H, CH2N), 5.93(s, 2H, CH2O2), 6.63-6.76(s, 3H, ArH).

後処理

  1. filtrationfiltered through a Celite layer
  2. temperatureto be cooled
  3. filtrationfiltered
  4. customto give solids
  5. washThe obtained solids were washed twice with 100 ml of cold water
  6. customdried

出典と根拠

ORDレコード
ord-cba18c7783e64b07b2d8f20d24a2f6f6
出典データセット
uspto-grants-1993_09
特許番号
US05242944

関連ノート

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