4-Iodobenzenesulfonyl chloride → 1-[(4-iodophenyl)sulfonyl]-4-methylpiperazine

HRID 502648ノート

反応式

HRID 502648 の反応式
[CH:1]1[C:6]([S:7](Cl)(=[O:9])=[O:8])=[CH:5][CH:4]=[C:3]([I:11])[CH:2]=1.[CH3:12][N:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1>C1COCC1>[I:11][C:3]1[CH:4]=[CH:5][C:6]([S:7]([N:16]2[CH2:17][CH2:18][N:13]([CH3:12])[CH2:14][CH2:15]2)(=[O:9])=[O:8])=[CH:1][CH:2]=1

参加物

4

反応物 2

HCID 73994-Iodobenzenesulfonyl chlorideHCID 531671-Methylpiperazine

生成物 1

HCID 37451491-[(4-iodophenyl)sulfonyl]-4-methylpiperazine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Pipsyl chloride (1.21 g, 4.0 mmol) was dissolved in THF (12 mL) and 4-methylpiperazine (1.1 mL, 12.2 mmol) was added dropwise. The resulting suspension was allowed to stir at RT over night. Filtration and washing with THF afforded crop 1 of compound 58. The mother liquors were concentrated, taken up in CH2Cl2, washed with H2O and brine, then dried over Na2SO4 to afford a second crop of compound 58.

後処理

  1. filtrationFiltration
  2. washwashing with THF afforded crop 1 of compound 58
  3. concentrationThe mother liquors were concentrated
  4. washwashed with H2O and brine
  5. dry with materialdried over Na2SO4

出典と根拠

ORDレコード
ord-06792456175c4a5aa36914bb7a9d00a0
出典データセット
uspto-grants-2010_08
特許番号
US07776867B2

反応ノート

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