Toluene → Methyl 3-[(cyclopropylamino)carbonyl]benzoate

HRID 502964ノート

反応式

HRID 502964 の反応式
[C:1]1([CH3:7])C=CC=C[CH:2]=1.[CH3:8][O:9][C:10]([C:12]1[CH:13]=[C:14]([C:18]([OH:20])=O)[CH:15]=[CH:16][CH:17]=1)=[O:11].S(Cl)(Cl)=O.C[N:26](C=O)C>C(Cl)(Cl)Cl>[CH:1]1([NH:26][C:18]([C:14]2[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=2)[C:10]([O:9][CH3:8])=[O:11])=[O:20])[CH2:2][CH2:7]1

参加物

6

反応物 4

HCID 1140TolueneHCID 6228DimethylformamideHCID 24386Thionyl ChlorideHCID 6018803-(Methoxycarbonyl)benzoic acid

生成物 1

HCID 47231565Methyl 3-[(cyclopropylamino)carbonyl]benzoate

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Toluene solution of 3-(Methoxycarbonyl)benzenecarboxylic acid, thionyl chloride and DMF (a catalytic amount) were heated under stirring. The reaction solution was dissolved in chloroform after evaporation under reduced pressure. After cyclopropylamine and triethylamine were added thereto and the whole was stirred at room temperature to obtain methyl 3-[(cyclopropylamino)carbonyl]benzoate.

後処理

  1. customafter evaporation under reduced pressure
  2. additionAfter cyclopropylamine and triethylamine were added
  3. stirringthe whole was stirred at room temperature

出典と根拠

ORDレコード
ord-7970b8c847374f64b42bda5eaa1518c8
出典データセット
uspto-grants-2010_08
特許番号
US07776897B2

反応ノート

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