5-Nitroindazole → HCID 178526490、化合物

HRID 503124ノート

反応式

HRID 503124 の反応式
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[NH:9][N:8]=[CH:7]2)([O-:3])=[O:2].[Br:13]N1C(=O)CCC1=O>C(Cl)(Cl)(Cl)Cl.N(C(C)(C)C#N)=NC(C)(C)C#N>[Br:13][C:7]1[C:6]2[C:10](=[CH:11][CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)[NH:9][N:8]=1

参加物

5

反応物 2

HCID 215015-NitroindazoleHCID 67184N-bromobutanimide

生成物 1

HCID 178526490HCID 178526490、化合物収率 130.5%

試薬・触媒・溶媒 2

HCID 6547Azobisisobutyronitrile触媒HCID 5943Carbon Tetrachloride溶媒

実験手順

To a solution of 12.4 g of 5-nitro-1H-indazole in 100 ml carbon tetrachloride were added 16.2 g of N-bromosuccinimide and 0.62 g of 2,2′-azobisisobutyronitrile, and the mixture was heated under reflux for 1 hour. The reaction mixture was cooled, and the resulting crystals were filtrated and washed with diethyl ether, to give 24.0 g of the title compound as a pale yellow powder.

後処理

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 1 hour
  3. temperatureThe reaction mixture was cooled
  4. filtrationthe resulting crystals were filtrated
  5. washwashed with diethyl ether

出典と根拠

ORDレコード
ord-7c7b136504e04d6e98f9c8620a3a4418
出典データセット
uspto-grants-2010_08
特許番号
US07776890B2

反応ノート

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