Water → HCID 59431290、化合物

HRID 505930ノート

反応式

HRID 505930 の反応式
O.C(=O)([O-])[O-].[K+].[K+].Br[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11].[CH3:15][C:16]1[NH:17][C:18]2[C:23]([CH:24]=1)=[C:22]([N+:25]([O-:27])=[O:26])[CH:21]=[CH:20][CH:19]=2>C(#N)C>[N+:25]([C:22]1[CH:21]=[CH:20][CH:19]=[C:18]2[C:23]=1[CH:24]=[C:16]([CH3:15])[N:17]2[CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])([O-:27])=[O:26]

参加物

6

反応物 4

HCID 962Water2 回HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 110951501H-Indole, 2-methyl-4-nitro-

生成物 1

HCID 59431290HCID 59431290、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
60 °C

実験手順

Water (4.5 ml), potassium carbonate (25.9 g, 187 mmol) and ethyl bromoacetate (20.8 ml, 188 mmol) were added sequentially to a suspension of 2-methyl-4-nitro-1H-indole (30 g, 170 mmol) in acetonitrile (225 ml) and the mixture heated at 60° C. for 16 hours. After allowing to cool to ambient temperature, water (225 ml) was added and the resulting mixture was broken up and then filtered. The solid was washed with water (2×75 ml), followed by IMS (2×75 ml) then dried in a vacuum oven to give (4-nitro-2-methyl-1H-indol-1-yl)-acetic acid, ethyl ester, 32.15 g (72%).

後処理

  1. temperatureto cool to ambient temperature
  2. filtrationfiltered
  3. washThe solid was washed with water (2×75 ml)
  4. customthen dried in a vacuum oven

出典と根拠

ORDレコード
ord-c3e1204296334c9ca75287e0612d163f
出典データセット
uspto-grants-2010_08
特許番号
US07781598B2

反応ノート

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