2-Methoxyethylamine → Tert-butyl 3-((2-methoxyethyl)amino)propanoate
反応式
[C:1]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])(=[O:4])[CH:2]=[CH2:3].[CH3:10][O:11][CH2:12][CH2:13][NH2:14]>CO>[CH3:10][O:11][CH2:12][CH2:13][NH:14][CH2:3][CH2:2][C:1]([O:5][C:6]([CH3:9])([CH3:8])[CH3:7])=[O:4]参加物
4
実験手順
tert-Butyl acrylate (4.4 ml) is dissolved in methanol (5 ml), and thereto is added 2-methoxyethylamine (3.1 ml). The mixture is stirred at room temperature for 3 hours. The reaction solution is concentrated under reduced pressure. The resulting residue is purified by distillation under reduced pressure to give tert-butyl 3-(2-methoxyethylamino)-propionate (4.61 g). Boiling point 98.0-102.0° C. (5.8 mmHg), MS (m/z): 204 [M+H]+.
後処理
- concentrationThe reaction solution is concentrated under reduced pressure
- distillationThe resulting residue is purified by distillation under reduced pressure
出典と根拠
- ORDレコード
- ord-1b2c01de4fd846739e00c910f0838718
- 出典データセット
- uspto-grants-2010_08
- 特許番号
- US07781443B2
反応ノート
読み込み中…