Water → HCID 178423844、化合物

HRID 506433ノート

反応式

HRID 506433 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10]([O:12]C)=[O:11])=[CH:4][CH:3]=1.Cl.[NH2:16]O.[OH-].[Na+].O>CO>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([OH:12])[O:11][N:16]=2)=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 291780Methyl 3-(4-methylphenyl)-3-oxopropanoateHCID 443297Hydroxyamine hydrochloride

生成物 1

HCID 178423844HCID 178423844、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

According to method of U.S. Pat. No. 3,781,438, 2 g of methyl 3-(4-methylphenyl)-3-oxopropanoate was dissolved in methanol, slightly excessive hydroxylamine hydrochloride and equivalent amount of sodium hydroxide were added, the mixture was heated to reflux. 3 hr later, the reaction was traced by Thin-Layer Chromatography, after the reaction, water was added to the reaction mixture, extracted with ethyl acetate, The combined organic extracts were dried and concentrated to obtain 3-(4-methylphenyl)isoxazol-5-ol as solid (compound III-3).

後処理

  1. temperaturethe mixture was heated to reflux
  2. custom3 hr
  3. additionwas added to the reaction mixture
  4. extractionextracted with ethyl acetate
  5. customThe combined organic extracts were dried
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-6372c26c00e94c609b4d3a29f03f5a7b
出典データセット
uspto-grants-2010_08
特許番号
US07786045B2

反応ノート

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