Methanol → Methyl 2-amino-2-phenylacetate hydrochloride

HRID 507435

反応式

HRID 507435 の反応式
[CH:1]1[CH:2]=[CH:3][C:4]([C@H:7]([NH2:11])[C:8]([OH:10])=[O:9])=[CH:5][CH:6]=1.S(Cl)([Cl:14])=O.[CH3:16]O>>[ClH:14].[CH3:16][O:9][C:8](=[O:10])[CH:7]([NH2:11])[C:4]1[CH:3]=[CH:2][CH:1]=[CH:6][CH:5]=1

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 99291L-Phenylglycine

生成物 1

HCID 12247454Methyl 2-amino-2-phenylacetate hydrochloride収率 97.6%

実験手順

To a stirred solution of (S)-phenylglycine (50 g, 0.3 mol) in MeOH (500 mL) at 0° C. was added thionyl chloride (42.84 g, 0.36 mol) dropwise. After stirring for 2 h, the solvent was concentrated, and the precipitated solid was washed with diethyl ether to afford product 8 (65 g, 97.6%). 1H NMR (400 MHz, D2O) δ 3.70 (s, 3 H), 5.17 (s, 1 H), 7.35-7.41 (m, 5 H).

後処理

  1. concentrationthe solvent was concentrated
  2. washthe precipitated solid was washed with diethyl ether

出典と根拠

ORDレコード
ord-b01c530cd25a4181945076016a52cbbb
出典データセット
uspto-grants-2010_08
特許番号
US07786163B2

関連ノート

読み込み中…