Ethanol → 1,2-Diethoxy-3-fluorobenzene

HRID 507881

反応式

HRID 507881 の反応式
[F:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:4]([OH:5])[C:3]=1[OH:9].[OH-].[Na+].[CH2:12](O)[CH3:13].Br[CH2:16][CH3:17]>ClCCl>[CH2:16]([O:5][C:4]1[CH:6]=[CH:7][CH:8]=[C:2]([F:1])[C:3]=1[O:9][CH2:12][CH3:13])[CH3:17]

参加物

6

反応物 4

HCID 702Ethanol2 回HCID 6332Ethyl BromideHCID 14798Sodium HydroxideHCID 677643-Fluorocatechol

生成物 1

HCID 224601261,2-Diethoxy-3-fluorobenzene収率 81%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
10 °C

実験手順

To a 500 ml flask were added 38.4 (0.3 mol) of 3-fluorocatechol [H], 12 g (0.3 mol) of sodium hydroxide and 100 ml of ethanol. After cooling to around 10° C., 100 ml of an ethanol solution of 76.3 g (0.7 mol) of bromoethane was slowly added. After the termination of the addition, they were reacted under a reflux temperature for 5 hours. After the termination of the reaction, dichloromethane was added, followed by extraction. The extraction liquid was washed with water and dried, and the solvent was removed by distillation to obtain 45.5 g of 1,2-diethoxy-3-fluorobenzene [G1] as an oily product. The process yield was 81%.

後処理

  1. additionAfter the termination of the addition, they
  2. customwere reacted under a reflux temperature for 5 hours
  3. additionwas added
  4. extractionfollowed by extraction
  5. extractionThe extraction liquid
  6. washwas washed with water
  7. customdried
  8. customthe solvent was removed by distillation

出典と根拠

ORDレコード
ord-d73a6277162945af817191edd1f34d31
出典データセット
uspto-grants-2010_08
特許番号
US07786330B2

関連ノート

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