Water → HCID 23157557、化合物

HRID 507979ノート

反応式

HRID 507979 の反応式
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH2:11][CH2:12][C:13]2=[O:18].[BH4-].[Na+].O>O1CCCC1.CO>[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[C:3]=1[C:9]1[CH:17]=[CH:16][CH:15]=[C:14]2[C:10]=1[CH2:11][CH2:12][CH:13]2[OH:18]

参加物

6

反応物 3

HCID 962WaterHCID 4311764Sodium borohydrideHCID 23157344HCID 23157344、化合物

生成物 1

HCID 23157557HCID 23157557、化合物収率 76.3%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

4-(2,6-Dimethylphenyl)indan-1-one (2.00 g, 8.47 mmol) was dissolved in a mixture of tetrahydrofuran (20 mL) and methanol (10 mL), sodium borohydride (449 mg, 11.9 mmol) was added, and the mixture was stirred at room temperature for 2 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was dried, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (5%-60% ethyl acetate/hexane) to give the title compound (1.54 g, yield 76%) as a colorless oil.

後処理

  1. additionwas added
  2. extractionthe mixture was extracted with ethyl acetate
  3. customThe extract was dried
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was purified by silica gel column chromatography (5%-60% ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-d1f0e4165c3c47d79d26112fc162bcb8
出典データセット
uspto-grants-2010_08
特許番号
US07786165B2

反応ノート

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