Ammonia → 2-Fluoro-4-(trifluoromethyl)benzamide

HRID 508835ノート

反応式

HRID 508835 の反応式
[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C(Cl)=O.[NH3:21]>C1COCC1>[F:1][C:2]1[CH:10]=[C:9]([C:11]([F:14])([F:13])[F:12])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:21])=[O:5]

参加物

5

反応物 3

HCID 222AmmoniaHCID 65578Oxalyl chlorideHCID 5180032-Fluoro-4-(trifluoromethyl)benzoic acid

生成物 1

HCID 6056892-Fluoro-4-(trifluoromethyl)benzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The title compound was prepared according to the procedure described in step-2 of Intermediate-26 by using 2-fluoro-4-(trifluoromethyl)benzoic acid (1.5 g), THF (25 mL), oxalyl chloride (0.5 mL) and ammonia gas to afford 1.35 g of the product. 1H NMR (300 MHz, DMSO d6): δ 7.65 (d, J=8.4 Hz, 1H), 7.77-7.84 (m, 3H), 7.96 (br s, 1H); MS (m/z): 208.06 (M+).

出典と根拠

ORDレコード
ord-f46f56fe03ff4d1fbc0d83953a4e1cc0
出典データセット
uspto-grants-2015_08
特許番号
US09096545B2

反応ノート

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