1-Benzyl-3-methyl-5-nitroindazole → 1-Benzyl-3-methyl-1H-indazol-5-ylamine

HRID 51104ノート

反応式

HRID 51104 の反応式
[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([N+:17]([O-])=O)=[CH:14][CH:15]=2)[C:10]([CH3:20])=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H][H]>C1COCC1.[Pt]>[CH2:1]([N:8]1[C:16]2[C:11](=[CH:12][C:13]([NH2:17])=[CH:14][CH:15]=2)[C:10]([CH3:20])=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 219521621-Benzyl-3-methyl-5-nitroindazoleHCID 178418361HCID 178418361、化合物

生成物 1

HCID 541033091-Benzyl-3-methyl-1H-indazol-5-ylamine

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 8028Tetrahydrofuran溶媒

実験手順

1-Benzyl-3-methyl-5-nitroindazole (0.15 g) in THF (15 ml) was treated with platinum on carbon (0.05 g, 5%) under an atmosphere of hydrogen at room temperature. When hydrogen uptake was complete, the mixture was filtered and concentrated in vacuo to give the title compound; m/z (M+1)+268.

後処理

  1. filtrationthe mixture was filtered
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-a27db1497aa14c7a81a366905b8197e2
出典データセット
uspto-grants-2004_03
特許番号
US06713485B2

反応ノート

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