反応式
FC(F)(F)C(O)=O.[F:8][C:9]([F:15])([F:14])[S:10]([OH:13])(=[O:12])=[O:11].COC1C=CC(C[S:23][CH:24]2[CH2:28][CH2:27][NH:26][C:25]2=[O:29])=CC=1>C1(OC)C=CC=CC=1>[F:8][C:9]([F:15])([F:14])[S:10]([OH:13])(=[O:12])=[O:11].[SH:23][CH:24]1[CH2:28][CH2:27][NH:26][C:25]1=[O:29]参加物
5
実験手順
20 ml of trifluoroacetic acid and 0.41 ml of trifluoromethanesulfonic acid were added, whilst ice-cooling, to a solution of 949 mg of 3-(4-methoxybenzylthio)pyrrolidin-2-one in 4 ml of anisole, and then the mixture was stirred at room temperature for 30 minutes. At the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure to leave a residue, which was purified by column chromatography through silica gel, eluted with a 10:1 by volume mixture of ethyl acetate and methanol, to give 728 mg of the title compound as an oil.
後処理
- concentrationAt the end of this time, the reaction mixture was concentrated by evaporation under reduced pressure
- customto leave a residue, which
- customwas purified by column chromatography through silica gel
- washeluted with a 10:1 by volume mixture of ethyl acetate and methanol
出典と根拠
- ORDレコード
- ord-715795a169ab49eca88ae924fb7a34b7
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05242914
関連ノート
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