3,4-Dichlorophenyl isocyanate → 4-(3,4-Dichlorophenylcarbamoyl)oxyimino-5-methyl-5-phenyl-3-phenylaminothiazolidine-2-thione

HRID 51218

反応式

HRID 51218 の反応式
[OH:1][N:2]=[C:3]1[C:7]([CH3:14])([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[S:6][C:5](=[S:15])[N:4]1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.C(N(CC)CC)C.[Cl:30][C:31]1[CH:32]=[C:33]([N:38]=[C:39]=[O:40])[CH:34]=[CH:35][C:36]=1[Cl:37]>O1CCCC1>[Cl:30][C:31]1[CH:32]=[C:33]([NH:38][C:39]([O:1][N:2]=[C:3]2[C:7]([CH3:14])([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[S:6][C:5](=[S:15])[N:4]2[NH:16][C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)=[O:40])[CH:34]=[CH:35][C:36]=1[Cl:37]

参加物

5

反応物 3

HCID 76073,4-Dichlorophenyl isocyanateHCID 8471TriethylamineHCID 865884954-Hydroxyimino-5-methyl-5-phenyl-3-phenylamino-thiazolidine-2-thione

生成物 1

HCID 865884964-(3,4-Dichlorophenylcarbamoyl)oxyimino-5-methyl-5-phenyl-3-phenylaminothiazolidine-2-thione

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 4-hydroxyimino-5-methyl-5-phenyl-3-phenylamino-thiazolidine-2-thione (0.19 g), triethylamine (0.06 g) and 3,4-dichlorophenylisocyanate in tetrahydrofuran (3 ml) was stirred for 2 days at room temperature. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography (chloroform) to yield 4-(3,4-Dichlorophenylcarbamoyl)oxyimino-5-methyl-5-phenyl-3-phenylaminothiazolidine-2-thione (0.13 g) having a melting point of 95-96° C.

後処理

  1. customThe solvent was evaporated under reduced pressure
  2. customthe residue was purified by column chromatography (chloroform)

出典と根拠

ORDレコード
ord-a3460076cd15444cb33a9bccf66d5f5a
出典データセット
uspto-grants-2004_03
特許番号
US06713629B2

関連ノート

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