Thionyl Chloride → 3,5-Dichloro-4-fluorobenzoyl chloride

HRID 512781ノート

反応式

HRID 512781 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:12])[C:10]=1[F:11])[C:5](O)=[O:6].S(Cl)([Cl:15])=O>CN(C=O)C.C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:12])[C:10]=1[F:11])[C:5]([Cl:15])=[O:6]

参加物

5

反応物 2

HCID 24386Thionyl ChlorideHCID 199713033,5-Dichloro-4-fluorobenzoic acid

生成物 1

HCID 196123793,5-Dichloro-4-fluorobenzoyl chloride

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6212Chloroform溶媒

実験手順

3,5-dichloro-4-fluorobenzoic acid was refluxed with >1 equivalent of thionyl chloride and one drop of DMF neat or as a solution in CHCl3. The solvent and volatile by-products were removed in vacuo to provide 3,5-dichloro-4-fluorobenzoyl chloride.

後処理

  1. customThe solvent and volatile by-products were removed in vacuo

出典と根拠

ORDレコード
ord-b35df1ffa7874a66994d292a8084a565
出典データセット
uspto-grants-2015_08
特許番号
US09102648B1

反応ノート

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