Sodium Hydroxide → 2-(4-fluorophenylthio)-N-cyclohexyl-N-phenylacetamide

HRID 51292

反応式

HRID 51292 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([SH:8])=[CH:4][CH:3]=1.[OH-].[Na+].Cl[CH2:12][C:13]([N:15]([CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:14]>O1CCCC1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:12][C:13]([N:15]([CH:22]2[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]2)[C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:14])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 677894-FluorothiophenolHCID 27949162-chloro-N-cyclohexyl-N-phenylacetamide

生成物 1

HCID 222511482-(4-fluorophenylthio)-N-cyclohexyl-N-phenylacetamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a stirred solution of 4-fluorothiophenol (0.13 mL, 1.2 mmol) in tetrahydrofuran (4 ml) was added aqueous 15% sodium hydroxide. 2-Chloro-N-cyclohexyl-N-phenylacetamide (320 mg, 1.3 mmol) was added, and the solution was stirred at room temperature for 16 hours. The solvent was removed under reduced pressure, and the residue purified on a preparatory plate using 20% ethyl acetate/hexanes to furnish 2-(4-fluorophenylthio)-N-cyclohexyl-N-phenylacetamide as a white solid. (M+1)=343.9

後処理

  1. customThe solvent was removed under reduced pressure
  2. customthe residue purified on a preparatory plate

出典と根拠

ORDレコード
ord-4ea92079631e47d4bb3b62aa87db6404
出典データセット
uspto-grants-2004_03
特許番号
US06713650B2

関連ノート

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