Sodium borohydride → 4-Chloro-furo[3,4-c]quinolin-1(3H)-one

HRID 5130ノート

反応式

HRID 5130 の反応式
[Cl:1][C:2]1[C:11]2[C:12](=[O:16])[O:13][C:14](=[O:15])[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[BH4-].[Na+]>O1CCCC1>[Cl:1][C:2]1[C:11]2[C:12](=[O:16])[O:13][CH2:14][C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1.[Cl:1][C:2]1[C:11]2[CH2:12][O:13][C:14](=[O:15])[C:10]=2[C:9]2[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=2[N:3]=1

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 541042384-Chloro-furo[3,4-c]quinoline-1,3-dione

生成物 2

HCID 112067664-Chloro-furo[3,4-c]quinolin-1(3H)-oneHCID 57030353HCID 57030353、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a well stirred mixture of 4-Chloro-furo[3,4-c]quinoline-1,3-dione (1.9 g) in tetrahydrofuran (10 mL) was added sodium borohydride (400 mg) at 0° C. and stirring was continued for 2 h. The reaction was then quenched with excess 6N HCl and water, and concentrated in vacuo to afford 4-Chloro-furo[3,4-c]quinolin-3(1H)-one as a pink solid along with a small quantity of 4-Chloro-furo[3,4-c]quinolin-1(3H)-one which could be isolated by column chromatography on silica gel.

後処理

  1. stirringstirring
  2. customThe reaction was then quenched with excess 6N HCl and water
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-fdab9219ef3743deb64f5cb01f5301ba
出典データセット
uspto-grants-1993_09
特許番号
US05243049

反応ノート

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