8-Aminoquinoline-7-carboxaldehyde → 1-(8-Amino-quinolin-7-yl)-propan-1-ol

HRID 513688

反応式

HRID 513688 の反応式
[NH2:1][C:2]1[C:3]([CH:12]=[O:13])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2.[CH2:14]([Mg]Br)[CH3:15]>C1COCC1>[NH2:1][C:2]1[C:3]([CH:12]([OH:13])[CH2:14][CH3:15])=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[CH:7]2

参加物

4

反応物 2

HCID 110520988-Aminoquinoline-7-carboxaldehydeHCID 178418443HCID 178418443、化合物

生成物 1

HCID 681831601-(8-Amino-quinolin-7-yl)-propan-1-ol収率 91%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In a similar fashion using route 27 general procedure 66, 8-amino-quinoline-7-carbaldehyde 404 (1 g, 5.83 mmol), ethyl magnesium bromide (3M in THF; 5.81 ml, 17.44 mmol) and THF (30 ml) gave the title compound (900 mg, 91%) after purification by column chromatography with DCM/MeOH (99:1) as the eluent.

出典と根拠

ORDレコード
ord-b95d17859f234fef9834127523f43a6a
出典データセット
uspto-grants-2015_08
特許番号
US09102688B2

関連ノート

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