Sodium Iodide → HCID 90447574、化合物

HRID 514804ノート

反応式

HRID 514804 の反応式
[CH2:1]([C:4]1([OH:17])[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]1)[CH:2]=[CH2:3].[Na+].[I-].C[Si](C)(C)[C:22]([F:25])(F)[F:23].C1COCC1>C(Cl)Cl>[F:23][C:22]1([F:25])[CH2:3][CH:2]1[CH2:1][C:4]1([OH:17])[CH2:9][CH2:8][N:7]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:6][CH2:5]1

参加物

6

反応物 4

HCID 5238Sodium IodideHCID 8028TetrahydrofuranHCID 552549(Trifluoromethyl)trimethylsilaneHCID 21955339Tert-butyl 4-allyl-4-hydroxypiperidine-1-carboxylate

生成物 1

HCID 90447574HCID 90447574、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
80 °C

実験手順

To a sealed tube was added tert-butyl 4-allyl-4-hydroxypiperidine-1-carboxylate 11B (280 mg, 1.16 mmol), NaI (112 mg, 0.74 mmol), trimethyl(trifluoromethyl)silane (0.6 mL) and THF (10 mL), The tube was sealed, and then the mixture was stirred at 80° C. overnight. The resulting mixture was diluted with DCM, filtered, and the filtrate was concentrated in vacuo to give the crude product 11C which was used for next step without further purification. LC-MS: m/z 292.3 (M+H)+

後処理

  1. customThe tube was sealed
  2. filtrationfiltered
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-f0c4ce2059ae482e8ce3a2cfa05d0b89
出典データセット
uspto-grants-2015_08
特許番号
US09108921B2

反応ノート

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