3-Phenoxytoluene → 1-Bromo-2-methyl-4-phenoxybenzene

HRID 51535

反応式

HRID 51535 の反応式
[O:1]([C:8]1[CH:9]=[C:10]([CH3:14])[CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[Br:15]N1C(=O)CCC1=O>C(#N)C>[C:2]1([O:1][C:8]2[CH:13]=[CH:12][C:11]([Br:15])=[C:10]([CH3:14])[CH:9]=2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 191653-PhenoxytolueneHCID 67184N-bromobutanimide

生成物 1

HCID 128585521-Bromo-2-methyl-4-phenoxybenzene収率 97.8%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of 3-phenoxytoluene (2.5 g, 0.0136 mol) and N-bromosuccinimide (2.54 g, 0.0142 mol) was stirred in acetonitrile (20 mL) for 2.5 hours under an atmosphere of nitrogen. The solvent was removed under reduced pressure. Carbon tetrachloride was added to the residue and the resulting solid was removed by filtration. The filtrate was concentrated to yield 4-bromo-3-methylphenyl phenyl ether as yellow oil (3.5 g, 0.0133 mol):

後処理

  1. customThe solvent was removed under reduced pressure
  2. additionCarbon tetrachloride was added to the residue
  3. customthe resulting solid was removed by filtration
  4. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-41372e57b62d4ee7b9f74314c3d1de09
出典データセット
uspto-grants-2004_03
特許番号
US06713474B2

関連ノート

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