Water → 4-[(2-Methylquinolin-4-yl)methoxy]benzoic acid

HRID 517521ノート

反応式

HRID 517521 の反応式
[OH-].[Na+].O.[CH3:4][C:5]1[CH:14]=[C:13]([CH2:15][O:16][C:17]2[CH:32]=[CH:31][C:20]([C:21]([O:23]CC3C=CC=CC=3)=[O:22])=[CH:19][CH:18]=2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=1>O1CCCC1.CO>[CH3:4][C:5]1[CH:14]=[C:13]([CH2:15][O:16][C:17]2[CH:32]=[CH:31][C:20]([C:21]([OH:23])=[O:22])=[CH:19][CH:18]=2)[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=1

参加物

6

反応物 3

HCID 962WaterHCID 14798Sodium Hydroxide2 回HCID 67056944HCID 67056944、化合物

生成物 1

HCID 220327754-[(2-Methylquinolin-4-yl)methoxy]benzoic acid収率 81%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

2.3 ml (18.6 mmol) of an 8N aqueous solution of sodium hydroxide and 5 ml of water are added to a solution of 3.6 g (9.3 mmol) of benzyl 4-(2-methylquinolin-4-ylmethoxy)benzoate diluted in 20 ml of tetrahydrofuran and 30 ml of methanol. The reaction medium is stirred at ambient temperature for 48 h then 1 ml of an 8N aqueous solution of sodium hydroxide is added and the mixture is heated at 70° C. for 5 h. After evaporation of the tetrahydrofuran, water and a 1N aqueous solution of acetic acid are added. The suspension is stirred overnight at ambient temperature then filtered. The solid obtained is dried under vacuum at 40° C. for 6 h. 2.2 g (81%) of 4-(2-methylquinolin-4-ylmethoxy)benzoic acid are obtained in the form of a white solid.

後処理

  1. temperaturethe mixture is heated at 70° C. for 5 h
  2. customAfter evaporation of the tetrahydrofuran, water
  3. additiona 1N aqueous solution of acetic acid are added
  4. stirringThe suspension is stirred overnight at ambient temperature
  5. filtrationthen filtered
  6. customThe solid obtained
  7. customis dried under vacuum at 40° C. for 6 h

出典と根拠

ORDレコード
ord-f7c789ba8bf442a9ae870cd428d7e24d
出典データセット
uspto-grants-2015_08
特許番号
US09115102B2

反応ノート

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