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Trifluoroacetic acid → 1-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate

HRID 517940
ノート
印刷プレビュー

反応式

HRID 517940 の反応式
[C:1]([C:3]1[C:8]2[N:9]=[N:10][N:11]([CH3:12])[C:7]=2[CH:6]=[C:5]([C:13]2[CH:34]=[CH:33][C:16]([O:17][CH2:18][CH2:19][CH:20]3[CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]3)=[C:15]([C:35]([F:38])([F:37])[F:36])[CH:14]=2)[N:4]=1)#[N:2].[C:39]([OH:45])([C:41]([F:44])([F:43])[F:42])=[O:40]>C(Cl)Cl.C(#N)C>[OH:45][C:39]([C:41]([F:44])([F:43])[F:42])=[O:40].[CH3:12][N:11]1[C:7]2[CH:6]=[C:5]([C:13]3[CH:34]=[CH:33][C:16]([O:17][CH2:18][CH2:19][CH:20]4[CH2:21][CH2:22][NH:23][CH2:24][CH2:25]4)=[C:15]([C:35]([F:38])([F:37])[F:36])[CH:14]=3)[N:4]=[C:3]([C:1]#[N:2])[C:8]=2[N:9]=[N:10]1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 6422Trifluoroacetic acidHCID 67294242tert-butyl 4-(2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl)piperidine-1-carboxylate

生成物 1

HCID 866733471-methyl-6-(4-(2-(piperidin-4-yl)ethoxy)-3-(trifluoromethyl)phenyl)-1H-[1,2,3]triazolo[4,5-c]pyridine-4-carbonitrile 2,2,2-trifluoroacetate

試薬・触媒・溶媒 2

HCID 6342Acetonitrile溶媒
HCID 6344
Dichloromethane
溶媒

実験手順

To tert-butyl 4-(2-(4-(4-cyano-1-methyl-1H-[1,2,3]triazolo[4,5-c]pyridin-6-yl)-2-(trifluoromethyl)phenoxy)ethyl)piperidine-1-carboxylate (6 g) in DCM (40 ml) and acetonitrile (20 ml) was added TFA (40 ml). The mixture was stirred at room temperature for 10 minutes, then solvent removed under vacuum. To the residue was then dissolved ethyl acetate (40 ml) and product was precipitated by adding ether (50 ml) and collected by filtration (6.05 g as TFA salt).

後処理

  1. customsolvent removed under vacuum
  2. customdissolved ethyl acetate (40 ml) and product was precipitated
  3. additionby adding ether (50 ml)
  4. filtrationcollected by filtration (6.05 g as TFA salt)

出典と根拠

ORDレコード
ord-37936b6326b84110bbf50dd0bb15b5e2
出典データセット
uspto-grants-2015_08
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US09115126B2

反応ノート

読み込み中…

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