Dimethylamine → 3-iodo-N,N-dimethylbenzamide
反応式
C[CH2:2][N:3]=[C:4]=NCCCN(C)C.Cl.CNC.C1COCC1.[I:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25](O)=[O:26]>O>[I:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[C:25]([N:3]([CH3:4])[CH3:2])=[O:26]参加物
6
実験手順
EDCl (1.3 g, 6.6 mmol) was added to a solution of dimethylamine in THF (2 M, 6 mL, 10 mmol) and 3-iodobenzoic acid (1.5 g, 6 mmol). After 18 h stirring the reaction was transferred into water, and then extracted with ethyl acetate. The organic phase was dried over sodium sulfate. The solvent was evaporated to afford the product as a viscous, clear oil. The product was used in the next reaction step without further purification. MS m/z: 276 [M+H].
後処理
- extractionextracted with ethyl acetate
- dry with materialThe organic phase was dried over sodium sulfate
- customThe solvent was evaporated
- customto afford the product as a viscous, clear oil
- customThe product was used in the next reaction step without further purification
出典と根拠
- ORDレコード
- ord-e079170cf6354df8ade8699268464eb9
- 出典データセット
- uspto-grants-2015_08
- 特許番号
- US09115147B2
反応ノート
読み込み中…