4-Fluorobenzoic Acid → 4-Fluoro-N-{4-methoxy-7-[methyl-(tetrahydro-pyran-4-ylmethyl)-amino]-benzothiazol-2-yl}-benzamide

HRID 51894ノート

反応式

HRID 51894 の反応式
[CH3:1][O:2][C:3]1[C:8]2[N:9]=[C:10]([NH2:12])[S:11][C:7]=2[C:6]([N:13]([CH3:21])[CH2:14][CH:15]2[CH2:20][CH2:19][O:18][CH2:17][CH2:16]2)=[CH:5][CH:4]=1.[F:22][C:23]1[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=1.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.C(N(C(C)C)C(C)C)C>C1COCC1>[F:22][C:23]1[CH:31]=[CH:30][C:26]([C:27]([NH:12][C:10]2[S:11][C:7]3[C:6]([N:13]([CH3:21])[CH2:14][CH:15]4[CH2:20][CH2:19][O:18][CH2:17][CH2:16]4)=[CH:5][CH:4]=[C:3]([O:2][CH3:1])[C:8]=3[N:9]=2)=[O:28])=[CH:25][CH:24]=1

参加物

6

反応物 4

HCID 99734-Fluorobenzoic AcidHCID 81531DiisopropylethylamineHCID 9886157Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)HCID 227370054-methoxy-N7-methyl-N7-(tetrahydro-pyran-4-ylmethyl)-benzothiazole-2,7-diamine

生成物 1

HCID 227370034-Fluoro-N-{4-methoxy-7-[methyl-(tetrahydro-pyran-4-ylmethyl)-amino]-benzothiazol-2-yl}-benzamide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

From 4-methoxy-N7-methyl-N7-(tetrahydro-pyran-4-ylmethyl)-benzothiazole-2,7-diamine with 4-fluorobenzoic acid, HATU and N-ethyldiisopropylamine in THF. ES-MS m/e (%): 430 (M+H+, 100).

出典と根拠

ORDレコード
ord-7445444b61ff4f8c8a6171c5a4827f10
出典データセット
uspto-grants-2004_03
特許番号
US06713499B2

反応ノート

読み込み中…