Hydrochloric Acid → Acetamide, 2-(hydroxyimino)-N-phenyl-

HRID 51980

反応式

HRID 51980 の反応式
[NH:1]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:4](=O)[C:2]1=[O:3].O=CC(Cl)(Cl)Cl.[Cl-].[OH:19][NH3+:20].Cl.NC1C=CC=CC=1>>[CH:8]1[CH:7]=[CH:6][C:11]([NH:1][C:2](/[CH:4]=[N:20]/[OH:19])=[O:3])=[CH:10][CH:9]=1

参加物

6

反応物 5

HCID 313Hydrochloric AcidHCID 6115AnilineHCID 6407ChloralHCID 7054IsatinHCID 21645Hydroxylamine HCl

生成物 1

HCID 6861488Acetamide, 2-(hydroxyimino)-N-phenyl-

実験手順

The isatin derivative (9) can be synthesized, for example, as shown in the following reaction scheme. That is, an aqueous solution obtained by adding chloral and hydroxylammonium chloride to hydrochloride of an aniline derivative (10) as a starting material is reacted for 0.5 to 2 hours with heating at 70° to 110° C. to give an isonitrosoacetanilide derivative, and this product is cyclized with concentrated sulfuric acid and hydrolyzed to give an isatin derivative (9). ##STR10## wherein R1A to R1D are as defined above.

後処理

  1. customas shown in the following reaction scheme
  2. customan aqueous solution obtained
  3. customis reacted for 0.5 to 2 hours
  4. temperaturewith heating at 70° to 110° C.

出典と根拠

ORDレコード
ord-e75f94cdfd09486eb81e090e8b1e9b65
出典データセット
uspto-grants-1997_04
特許番号
US05616441

関連ノート

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