反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][C:12]2[C:25]([C:26]([O:28]CC=C)=[O:27])=[C:16]3[C:17]([C:21]([CH2:23][CH3:24])=[S:22])=[C:18]([CH3:20])[O:19][C:15]3=[CH:14][CH:13]=2)[N:4]=1.CC1(C)CC(=O)CC(=O)C1>O1CCCC1>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][C:12]2[C:25]([C:26]([OH:28])=[O:27])=[C:16]3[C:17]([C:21]([CH2:23][CH3:24])=[S:22])=[C:18]([CH3:20])[O:19][C:15]3=[CH:14][CH:13]=2)[N:4]=1参加物
4
実験手順
1.60 g of allyl 5-(4,6-dimethoxypyrimidin-2-yl)oxy-3-ethylthiocarbonyl-2-methylbenzofuran-4-carboxylate and 0.54 g of dimedone were dissolved in 14 ml of tetrahydrofuran, and 40 mg of tetrakistriphenylphosphine palladium (0) was added thereto under a nitrogen atmosphere. The mixture was stirred at room temperature for 3 hours. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=2/1) to obtain 1.33 g (yield: 91%) of the desired compound.
後処理
- concentrationThe reaction solution was concentrated under reduced pressure
- customthe residue was purified by silica gel column chromatography (n-hexane/ethyl acetate=2/1)
出典と根拠
- ORDレコード
- ord-20301908661145a2bcc9f8c17eecf4a7
- 出典データセット
- uspto-grants-1997_04
- 特許番号
- US05616537
関連ノート
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