Hydrochloric Acid → HCID 10397731、化合物

HRID 520455ノート

反応式

HRID 520455 の反応式
[OH-].[Na+].Cl.[CH3:4][NH2:5].O=C1[NH:12][C:11]2[C:13]([C:17](O)=[O:18])=[CH:14][CH:15]=[CH:16][C:10]=2[C:9](=[O:20])[O:8]1.Cl>O>[NH2:12][C:11]1[C:13]([C:17](=[O:18])[NH:5][CH3:4])=[CH:14][CH:15]=[CH:16][C:10]=1[C:9]([OH:8])=[O:20]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 6364545Methylamine hydrochlorideHCID 103529652,4-Dioxo-1,4-dihydro-2H-3,1-benzoxazine-8-carboxylic acid

生成物 1

HCID 10397731HCID 10397731、化合物収率 86%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Aq NaOH (23.4 mL, 46.8 mmol) was added to a solution of methylamine hydrochloride (3.52 g, 53.7 mmol) in H2O (37 mL). 2,4-dioxo-2,4-dihydro-1H-benzo[d][1,3]oxazine-8-carboxylic acid 29 (3.23 g, 15.6 mmol) was in portions. After addition was complete, the solution was stirred at ambient temperature for 1.5 h. 6M HCl was added until pH=3. The resulting precipitate was collected by filtration, rinsed with H2O and dried to give 31 (2.60 g, 86% yield).

後処理

  1. additionAfter addition
  2. filtrationThe resulting precipitate was collected by filtration
  3. washrinsed with H2O
  4. customdried

出典と根拠

ORDレコード
ord-0bb580d010c945bc85e05c24183c3485
出典データセット
uspto-grants-2016_05
特許番号
US09326986B2

反応ノート

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