Thionyl Chloride → 1,4-Dimethyl-1H-pyrazole-3-carbonyl chloride

HRID 520597

反応式

HRID 520597 の反応式
[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[C:4]([C:8]([OH:10])=O)=[N:3]1.S(Cl)([Cl:13])=O>>[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[C:4]([C:8]([Cl:13])=[O:10])=[N:3]1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 53256851,4-Dimethyl-1H-pyrazole-3-carboxylic acid

生成物 1

HCID 583563801,4-Dimethyl-1H-pyrazole-3-carbonyl chloride

実験手順

1,4-Dimethyl-1H-pyrazole-3-carboxylic acid (190 mg) was weighed to a round bottom flask and thionyl chloride (1 ml) was added. The reaction was heated to reflux for 6 h then overnight at RT. After this time thionyl chloride was evaporated and the residue azeotroped with toluene to afford the title compound, 200 mg.

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux for 6 h
  3. customovernight
  4. customat RT
  5. customAfter this time thionyl chloride was evaporated
  6. customthe residue azeotroped with toluene

出典と根拠

ORDレコード
ord-c376dc8ae7c445a988d94f474b950868
出典データセット
uspto-grants-2016_05
特許番号
US09326987B2

関連ノート

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