Oxetane → 6-Phenyl-1-hexanol
反応式
Br[CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[Mg].[O:12]1[CH2:15][CH2:14][CH2:13]1.[NH4+].[Cl-]>C1COCC1>[C:5]1([CH2:4][CH2:3][CH2:2][CH2:15][CH2:14][CH2:13][OH:12])[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1参加物
6
実験手順
(3-Bromopropyl)benzene (20 g) in THF (75 ml) was added dropwise to magnesium (2.43 g) at a rate to maintain gentle reflux. The mixture was stirred for 2 h at RT and oxetane (10 g) was added dropwise. The resulting suspension was stirred at RT for 2h and at reflux for 16 h and poured into saturated aqueous NH4Cl (100 ml). The mixture was extracted with ER (3×75 ml) and the dried extract was evaporated to leave a yellow oil. Distillation of the oil gave the title compound as a colourless liquid (6.05 g) b.p. 100-105°/0.4 mmHg. T.l.c. [O] 0.3.
後処理
- temperatureto maintain gentle reflux
- temperatureat reflux for 16 h
- extractionThe mixture was extracted with ER (3×75 ml)
- extractionthe dried extract
- customwas evaporated
- customto leave a yellow oil
- distillationDistillation of the oil
出典と根拠
- ORDレコード
- ord-5c394360b9934f6ea34c45ca866ffcda
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05243076
反応ノート
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