Lithium Hydroxide → 3-Bromo-5-fluoro-4-methoxybenzoic acid
反応式
C[O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([F:10])[C:7]([O:11][CH3:12])=[C:6]([Br:13])[CH:5]=1.[OH-].[Li+]>C1COCC1.O>[Br:13][C:6]1[CH:5]=[C:4]([CH:9]=[C:8]([F:10])[C:7]=1[O:11][CH3:12])[C:3]([OH:14])=[O:2]参加物
5
実験手順
5.8 g of the product obtained in step 2 were dissolved in 100 ml of a mixture of THF and water (9:1), 1.06 g (44.1 mmol) of lithium hydroxide were added and the mixture was stirred for 3 days. The solvent was evaporated and the residue was purified by preparative RP HPLC (water/ACN gradient). 2.9 g of the title compound were obtained.
後処理
- additionwere added
- customThe solvent was evaporated
- customthe residue was purified by preparative RP HPLC (water/ACN gradient)
出典と根拠
- ORDレコード
- ord-d31e83c6bfd441a7b3b90f4fb51053a9
- 出典データセット
- uspto-grants-2016_05
- 特許番号
- US09328071B2
反応ノート
読み込み中…